Per this
http://www.sports-reference.com/cbb/play-index/matchup_finder.cgi?request=1&year_min=1950&year_max=2016&school_id=clemson&opp_id=south-carolina&comp_school=le&rank_school=ANY&comp_opp=le&rank_opp=ANY&game_type=A&game_month=&game_location=&game_result=&is_overtime=&order_by=date_game
Yes.