Your choices may be dependent on your age and health care needs. I work in an ICU, and never thought about it until I turned 60 and thought about all the people who had medical emergencies while on vacation in Charleston. If you don’t have any issues your choices are wide open. If you’re older and/or have health issues, you’re better off having a heart attack in Boston rather then Belize.
If I were in your shoes and had two weeks to travel, I’d do one of two things.
1) Lots of things to see here in the US. One thing I’m planning on doing when I retire is traveling the old Route 66 cross country. So many other things I’d like to see, would love to drive through Arizona and Utah. I’d like to see places like Yosemite, Sequoia, and Yellowstone. The Keys are always a good bet, lots to do there if you like a tropical climate. I’d love to catch baseball games at Yankee Stadium, Wrigley Field, and Fenway Park. Always wanted to go up around Maine. I’d love to go back to upper Washington close to the border, do some more whale watching. I’ve never been to California wine country, would like to do that.
2) With two weeks off, there’s a lot to do in Europe. I’d love to go back to Italy, you could easily spend two weeks just seeing Rome, the Ulysses Riviera between Rome and Naples, Florence, or the Amalfi Coast. Catch a train, you can see a lot. Couldn’t fit it all into two weeks, but I’d like to visit Greece, Austria, Belgium, Spain, Ireland, Scotland, Germany....you get the point. Lots to see.