I'd like to, respectively, disagree with Simpsonville due to traffic/travel logistics...although it is a great little town/suburb of Greenville. While I agree it's close and nice, driving to Spartanburg will pit you through multiple problem zones everyday (unless you're working in the southern part of Spartanburg and can use smaller, 2-lane roads to access - which are an adventure by themselves...and definitely not the shortest routes!
If you're working in Spartanburg, you'll want easier access to I-85 and to avoid the most problematic "backup" areas in Greenville: the 385/85 junction, and 85 between Woodruff Rd/Pelham Road. For simply convenience, the Pelham Road area is a nice offering once you learn to avoid the inherent traffice problems of the Eastside. Once you work your way to the to 85 at Hwy 14, it's smooth sailing to Spartanburg (and the reverse).
My wife and I have had once had the same scenario with my office being in downtown Greenville, and she working in Spartanburg. We moved to Greenville 9 years ago south of 85 between Hwy 14 and Five Forks on Batesville Road. There's great neighborhoods all there with easy access to Five Forks, Pelham Road, and the dreaded Woodruff Road (once you know where not to get on!). If you're looking for schools, etc, there's much more I can help you with.
The north side of 85 along Batesville/Pelham also has a great collection of neighborhoods in a myriad of price points. My recommendation is connect with a good realtor/banker/investor in Greenville to give you a highlight of them all. What you'll find is Greenville's an incredible growing town with a ton going on....but for just "ease" of driving, the Eastside is a good recommendation. Other nice areas are the Augusta Road area and North Main district - but will add a little more "creativity" to your drive.
Let me know if I can do anything to help - long term Upstate native who's very involved in Greenville (not a realtor - no sales interest). And welcome to the Upstate!
*** Sorry, in full disclosure I didn't see your wife was going to be in Anderson - I'd probably get a feel more for your job flexibility and time at work before making a full recommendation. But overall, I can't imagine living in Anderson or Spartanburg over Greenville (and I grew up in one of those!)**
This post was edited on 3/19 4:52 PM by Verticle Rooster